Optimization of NP Synthesis/Isolation/Purification/Characterization Preclinical and clinical development of NP is often hampered by the low quantities of samples available from natural sources. The bewildering diversity of natural product structures continues to stimulate and challenge chemists to invent new reactions, reagents and strategies to tackle the challenges that nature provides. The total synthesis of a natural product may lead to the identification of a sub-structural portion of the molecule bearing the essential pharmacophoric features necessary for activity whereas semi-synthetic structural modifications of the NP often provide important structure activity relationships (SAR) that enable subsequent computer-aided ligand optimization and the synthesis of analogues with improved pharmacological properties. Recent prominent examples of this approach are eribulin mesylate, a synthetic analogue of a sub-unit of the complex marine natural product halichondrin B, and the development of an efficient strategy to synthesize (–)-deoxytetracycline, which has enabled the preparation of hundreds of tetracycline congeners, some of which have successfully passed the phase 2 clinical trial. 

 

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 MEMBERS 

 Markus Kalesse     (Group leader) 
 Brunp Botta
Mattia Mori 
Annette Bayer
Oleg Melnyk
Edgars Suna
Aleksander Veselinović
Stephen Clark
Danijel Kikelj
Janez Ilaš
Efstathia Ioannou
Vassilios Roussis
Christos Petrou
Nikolas Fokialakis
Nevena Veljkovic  
Jean-Christophe Monbaliu
Ari Koskinen
Gerard McGlacken
Patricia Rijo
Soren Christensen 
Wim Dehaen
Abdullatif Azab
Mercedes Amat
Arif Kivrak
Bastien Nay
Mark Broenstrup
Camelia Bala
Filipa Marcelo
Ivanka Tsakovska
Joan Bosch
Karl-Heinz Altmann
Maurizio Botta 
Martin Maier 
Ilza Pajeva
Maria Santos
Patrick Trouillas
Dionisios Vourloumis
Raivis Zalubovskis
Attila Hunyadi
Grzegorz Grynkiewicz
Bengt Erik Haug
Pekka Joensuu
Vladimir Kren
Maija Lahtela-Kakkonen
Nihan Çelebi-Ölçüm
Maria João Ramos
Tapio Nevalainen
Trond Vidar Hansen
Yngve Stenstrøm
Deniz Tasdemir
Vladimir Dimitrov
Georgi Dobrikov
Manuela Tosin
Maria Mastihubova
Rob Field
Emmanuel Pitsinos
Sylvie Michel
Pavel Drasar
Guillaume Vincent
Daniele Passarella
John Moses
Miroslav Sisa
Angel de Lera
Arnaud Haudrechy
Papaioannou Dionissios
Francisca Vicente Perez
Hans Dieter Arndt
Jean Francois Poisson
Johan Vander Eycken
Michel Baltas
Josep Bonjoch
Jose Vicario
Marco Bandini
Maria Ferreira
Sergio Riva
Victor Martin
Vittorio Pace
Parvulescu  Vasile 
Cristina Nativi 
Gilles Hanquet 
Rosano Camillo 
Csampai Antal
Zhu Jieping 
Ines Primozic